Molecular Diagnosis for Personalized Target Therapy in Gastric Cancer
نویسندگان
چکیده
منابع مشابه
Molecular Diagnosis for Personalized Target Therapy in Gastric Cancer
Gastric cancer is the second leading cause of cancer-related deaths worldwide. In advanced and metastatic gastric cancer, the conventional chemotherapy with limited efficacy shows an overall survival period of about 10 months. Patient specific and effective treatments known as personalized cancer therapy is of significant importance. Advances in high-throughput technologies such as microarray a...
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Gastric cancer is the fifth most frequently diagnosed cancer and the third leading cause of cancer mortality. In advanced gastric cancer patients, the treatment outcomes are dismal. With the development of the molecular targeted therapy, the prognosis in patients with advanced and unresectable gastric cancer are improved. This article reviewed the molecular targeted agents in clinical use, thei...
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Gastric cancer (GC) is regarded as the fifth most common cancer and the third cause of cancer-related deaths worldwide. Mechanism of GC pathogenesis is still unclear and relies on multiple factors, including environmental and genetic characteristics. One of the most important environmental factors of GC occurrence is infection with Helicobacter pylori that is classified as class one carcinogens...
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Genomic studies have provided key insights into how cancers develop, evolve, metastasize, recurrence and respond to treatment. The advance of liquid biopsy using circulating tumor DNA (ctDNA), the next-generation sequencing (NGS) and bioinformatics has led to an unprecedented view of the cancer genome and its evolution, and made the dynamic monitoring of recurrence and selective evolution of ca...
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Gastric cancer (GC) represents a major cancer burden worldwide, and remains the second leading cause of cancer-related death. Due to its insidious nature, presentation is usually late and often carries a poor prognosis. Despite having improved treatment modalities over the last decade, for most patients only modest improvements have been seen in overall survival. Recent progress in understandin...
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ژورنال
عنوان ژورنال: Journal of Gastric Cancer
سال: 2013
ISSN: 2093-582X,2093-5641
DOI: 10.5230/jgc.2013.13.3.129